What is Targeted Therapy for Cancer Treatment?
Targeted anticancer agents are drugs that produce their anticancer effect by selectively modifying a target key to the growth of cancer cells. Cancer is a heterogeneous disease, that is, all individuals with the same cancer type do not contain the same mutations/alterations. Thus, the targeted therapy is designed to target a specific alteration/mutation. It helps in the selective destruction of cancer cells while sparing normal cells, which leads to a decrease in the side effects.
Patients who harbour a specific genetic/molecular alteration are generally considered as the suitable candidate for targeted cancer therapy. For assessing the most suitable candidates for targeted cancer therapy, molecular testing may be done, which helps in the detection of various genetic or epigenetic alterations, expression of certain defective proteins, or other defects in the cancer cells at the molecular level for which a targeted drug is available. In some cases, especially when the disease is not responding to standard treatment, targeted therapy may be helpful to prolong the survival of cancer patients.
Targeted drugs are considered to be relatively safer and better tolerated than standard chemotherapeutic drugs as they are directed towards the specific molecular targets associated with the cancer cells. Thus, normal cells are spared by these drugs leading to a lower number (or less intensity) of side effects compared to those caused by standard chemotherapeutic agents.
What are the cancer types in which Targeted Therapy is used and what are the various types of targeted therapies available for them?
Role of Targeted Therapy in STOMACH AND ESOPHAGEAL CANCER
Role of Targeted Therapy in COLORECTAL CANCER
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